Cancer genetics and molecular diagnostics

Mozhdeh Rastegari

Ph.D. Candidate in Molecular Genetics

A molecular genetics researcher focused on cancer biology, connecting fundamental genetic knowledge with clinical and industrial applications in diagnostic kits, oncology research, and genomic data analysis.

7+ Research articles
4 years University teaching
2 years Quality control leadership

Profile

Researcher at the intersection of genomics, cancer biology, and applied diagnostics.

My professional approach is centered on bridging fundamental genetics and clinical or industrial application, especially in cancer research and diagnostic kit production. I work with molecular genetic techniques, bioinformatics workflows, and regulated quality control processes to translate molecular evidence into practical decisions.

Cancer biology Molecular genetics Clinical diagnostics

Research expertise

Cancer genetics with an emphasis on lung and breast cancer.

The core research direction is the study of single nucleotide polymorphisms, genetic markers, and expression patterns that affect susceptibility, tumor progression, prognosis, metastasis, and treatment sensitivity.

Genetic markers

Investigation of genetic markers in lung and breast cancer, with attention to clinically meaningful associations.

Metastasis-related polymorphisms

Study of polymorphisms in genes involved in invasion and metastasis, including MMP9-related variants.

Prognosis and therapy response

Analysis of genetic and transcriptomic variation in relation to patient survival, prognosis, and treatment sensitivity.

Technical strengths

A lab-to-data skill set for molecular research and diagnostic production.

Bioinformatics and data

  • Cancer genomic and transcriptomic analysis
  • R programming for biological data
  • Differential gene expression analysis

Molecular genetics

  • PCR and advanced applications
  • DNA and RNA extraction protocols
  • RFLP
  • Gene cloning fundamentals and practice
  • CRISPR-Cas9 gene editing
  • Basic and advanced cell culture

Industrial diagnostics

  • Quality control management for diagnostic kit production
  • Regulatory and industrial documentation for manufacturing licenses

Protein analysis

  • Protein spectrophotometry
  • Soluble protein extraction from bacteria
  • Lowry and Biuret protein quantification

Certificates

A curated gallery of scientific training, workshops, and professional certificates.

The certificates are presented in a polished visual archive, preserving the original documents while organizing them by scientific theme and training focus.

Regenerative Medicine
01 Regenerative medicine

Regenerative Medicine

Virtual course, August 2024 to January 2025, 52 sessions and 104 instructional hours.

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Introduction to Bioinformatics
02 Bioinformatics

Introduction to Bioinformatics

Online course, February 2025 to July 2025, 59 sessions and 120 instructional hours.

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Quality Control for Cosmetics, Hygiene Products, and Detergents
03 Quality control

Quality Control for Cosmetics, Hygiene Products, and Detergents

Online course by Iranian Microbiology Academy, May to July 2025, 10 sessions.

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Comprehensive Gene Therapy: from Genetic Engineering and Genome Editing to Disease Treatment
04 Gene therapy

Comprehensive Gene Therapy: from Genetic Engineering and Genome Editing to Disease Treatment

Virtual course, October 2022 to March 2023, 36 sessions and 72 hours.

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Second International and Fourth National CRISPR Symposium
05 CRISPR

Second International and Fourth National CRISPR Symposium

Includes Principles of Gene Editing and sgRNA Design workshop, 20-21 June, NIGEB, Tehran.

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Comprehensive Design, Manufacturing, and Quality Control of Vaccine Platforms
06 Vaccine platforms

Comprehensive Design, Manufacturing, and Quality Control of Vaccine Platforms

Virtual course held from July to November 2022 in 36 sessions.

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Gene Therapy and CRISPR Workshop
07 Gene therapy

Gene Therapy and CRISPR Workshop

Two-day workshop, May 18 and 19, 2022, Tehran, Iran.

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Gene Therapy, Functions and Applications
08 Gene therapy

Gene Therapy, Functions and Applications

Workshop organized by Nour Medical Genetics Center and Iranian Academy of Genetic, March 31, 2022.

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CRISPR Workshop
09 CRISPR

CRISPR Workshop

Two-hour workshop organized by Iranian Academy of Genetic, February 28, 2022.

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Principles of Genetic Counseling
10 Genetic counseling

Principles of Genetic Counseling

Two-hour workshop organized by Iranian Academy of Genetic, February 13, 2021.

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Biosafety Considerations of Cell and Gene Therapy
11 Biosafety

Biosafety Considerations of Cell and Gene Therapy

Workshop organized by the Iranian Biotechnology Society, October 20, 2021, Tehran.

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6th Virtual Symposium of Genetics and Stem Cell Tending to Gene Therapy
12 Stem cell

6th Virtual Symposium of Genetics and Stem Cell Tending to Gene Therapy

Certificate of participation, 19-20 May 2021.

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Awareness and Attention to Genetic Diseases
13 Scientific training

Awareness and Attention to Genetic Diseases

Educational workshop held on 22 Farvardin 1401 by the Scientific Biology Association.

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Acceptance of Lung Cancer Palliative Care Article
14 Conference acceptance

Acceptance of Lung Cancer Palliative Care Article

Acceptance for the 10th International Conference on Health, Treatment and Health Promotion, Georgia, 07 July 2022.

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Selected articles

Research output drawn from the document archive.

These publication highlights were organized from the files in the doc folder and summarized for a clear personal website presentation.

01

The role of long non-coding RNAs in predicting survival of breast cancer patients: a review study

Review study | Breast cancer survival

Reviews how long non-coding RNAs may act as prognostic biomarkers by reflecting tumor biology, treatment response, metastasis, and survival-related pathways.

Breast cancer | lncRNA | Prognosis
02

Prognostic significance of CHCHD2P9 and ZNF204P in breast cancer

Molecular Biology Reports, 2024 | DOI: 10.1007/s11033-024-09643-x

Identifies dysregulated non-coding RNAs in breast cancer, validates CHCHD2P9 and ZNF204P expression changes, and links them to survival and malignancy pathways.

ncRNA | Breast cancer | Survival
03

Role of palliative care in the quality of life in lung cancer patients in Iran

2022 | Lung cancer and quality of life

Evaluates how palliative care relates to quality of life indicators among Iranian lung cancer patients, with attention to treatment satisfaction and social relationships.

Lung cancer | Palliative care | Iran
04

Effects of pomegranate juice with and without aerobic training on glycemic control and lipid profile in women with type 2 diabetes

2020 | DOI: 10.22037/amls.v6.30381

Studies the combined effect of pomegranate juice and aerobic training on fasting glucose, HbA1c, triglycerides, and related metabolic markers.

Diabetes | Aerobic training | Lipid profile
05

Investigation of insulin-like growth factors and binding proteins regulation in metabolic syndrome patients

BMC Research Notes, 2019 | DOI: 10.1186/s13104-019-4492-9

Explores associations between IGF and IGFBP levels, metabolic parameters, and the risk profile of metabolic syndrome.

Metabolic syndrome | IGF | Biomarkers
06

Functional SNP in microRNA-491-5p binding site of MMP9 3-prime UTR affects cancer susceptibility

Journal of Cellular Biochemistry, 2017 | PMID: 29091292

Reports how rs1056628 in the MMP9 3-prime UTR may alter miR-491-5p regulation and affect susceptibility to gastric, breast, and lung cancers.

MMP9 | miRNA | SNP
07

Evaluation of -1562 C/T promoter polymorphism of the MMP-9 gene and lung cancer initiation and metastasis risk

Pars Journal of Medical Sciences, 2017

Examines the relationship between MMP-9 promoter polymorphism and lung cancer risk, including metastasis analysis in a case-control design.

Lung cancer | MMP-9 | PCR-RFLP

Experience

Academic, diagnostic, and research work.

Quality Control Manager

Vista Biotechnology Beh Gene Company | 2 years

Designed, implemented, and monitored quality control tests for diagnostic kit production lines and regulatory readiness.

University Lecturer

Zand Higher Education Institute, Shiraz | 4 years

Taught university-level courses and supported students in molecular biology and genetics-related learning paths.

Research Expert

Mohebbin Hazrat Abbas Charity Educational and Rehabilitation Institute

Contributed to research activities, documentation, and applied scientific workflows in an educational and rehabilitation setting.

Collaboration

Built for research identity, publication visibility, and future collaboration.

This website presents a bilingual professional profile.

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